منابع مشابه
Mode of action of new anti-arrhythmic agents.
Propranolol, diphenylhydantoin and tetrodotoxin showed inhibitory or removal effects on fibrillation induced in isolated rabbit atrial muscle strip. Depending upon methods of induction of fibrillation, effects of these drugs were different. The mode of their action seemed to be due to following electrical natures of each drug in its effective dose. Diphenylhydantoin decreased rate of rise and a...
متن کامل1 . The Mode of Action of Chemotherapeutic Agents
G. M. FINDLAY, in opening the discussion, said that chemotherapeutic action might be classified as direct or indirect. Except in the case of parasites present in the intestinal canal it was essential that the chemotherapeutic drug should be absorbed into the body, that it should penetrate to the site where the parasites were acting, and that it should not be excreted or converted into an inert ...
متن کاملMode of Action of Chronotropic Agents in Cardiac Purkinje Fibers
Hauswirth et al. (1968) proposed that epinephrine acts on i(KK2) by adding its own positive charge to the external membrane surface near the i(KK2) channel. This hypothesis was tested by using noncationic compounds, theophylline and R07-2956, which mimicked epinephrine's effects on pacemaker activity and on i(KK2). In maximally effective doses, theophylline or R07-2956 occluded the effect of ep...
متن کاملAntifungal agents: mode of action in yeast cells.
Different kinds of mycoses, especially invasive, have become an important public health problem as their incidence has increased dramatically in the last decades in relation to AIDS, hematological malignancies, transplant recipients and other immunosuppressed individuals. Management of fungal infections is markedly limited by problems of drug safety, resistance and effectiveness profile. Curren...
متن کاملCationic lipids and surfactants as antifungal agents: mode of action.
OBJECTIVES To determine the mechanism of antimicrobial action for cationic lipid dioctadecyldimethylammonium bromide (DODAB) and hexadecyltrimethylammonium bromide (CTAB) against Candida albicans. METHODS Determination of DODAB or CTAB adsorption isotherms; cell viability; cell electrophoretic mobility (EM); and leakage of small phosphorylated compounds, proteins or DNA from fungus or haemogl...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1969
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)94325-5